Endocrine Abstracts

Introduction: Hyperthyroidism is the condition that occurs due to excessive release of thyroid hormone by the thyroid gland. Anti-thyroid drugs are usually the first choice of the treatment but surgery and radioactive iodine can also be used in treatment of hyperthyroidism. Plasmapheresis is a rapid and effective treatment option in cases where immediate euthyroidism is needed to be obtained due to complications of thyrotoxicosis and major side effects of antithyroid drugs.</p...

Background and aim: Pheochromocytoma, is a catecholamine-producing tumor, may rarely secrete other hormones such as adrenocorticotropic hormone (ACTH). We aimed to report a rare case of ectopic cushing syndrome due to malignant pheochromocytoma.Case report: A 42-year-old man admitted to outpatient clinic with headache, irritability, vomiting, nausea, and palpitation. He had paroxysmal hypertension and urinary fractionated metanephrines were measured appr...

Introduction: Fahr disease, is a rare pathology characterized by neuropsychiatric symptoms and bilateral symmetrical intracranial, especially basal ganglial calcifications. Although the exact etiology is not known, it is often associated with calcium and phosphorus metabolism disorders. We aim to present two brothers who presented with Fahr’s disease which is a rare condition.Case: Sixty-year-old male patient without a medical history of ilness was ...

Introduction: Autoimmune polyglandular syndrome type 2 (APS2) is the most common form of the polyglandular failure syndromes. Seventy-five percent of cases occur in women. Adrenal insufficiency is the principal manifestation occurs with autoimmune thyroid disease or type I diabetes mellitus. The incidence of autoimmune thyroid diseases in APS2 is 70%; 30% Hashimoto’s thyroiditis, 20% non toxic goiter, 20% hypertyroidism is seen. We will discuss about a patient with APS2, ...

Diabetes insipidus (DI) is a rare disorder which is characterized with inability to concentrate urine because of severe liquid-balance impairment. Mutations in AVPR2 gene is one of the causes of DI. AVPR2 is a G protein coupled receptor (GPCR) and its specific agonist is arginine vasopressin (AVP). When AVP binds to the AVPR2, which locates on the basolateral side of collecting duct principal cells of the kidney, it triggers accumulation of cAMP in the cell as a seconder messe...

Changes in arginine vazopression type 2 receptor (AVPR2) gene mostly lead to a rare hereditary polyuric disease, X-linked nephrogenic diabetes insipidus (NDI). The disease is characterized by the production of large amounts of urine and an inability to concentrate urine in response to the antidiuretic hormone vasopressin. In our previous study we have identified a novel 388 bp deletion in the AVPR2 gene in a patient with NDI and in his family. For fu...

Diabetes is an important risk factor for ischemic stroke. Hyperglycemia observed in acute ischemic stroke is accepted as a poor prognostic factor. In the present study, our aim is to investigate the effect of diabetes on the duration and cost of treatment in acute ischemic stroke.Three hundred sixty two acute ischemic stroke patients that were hospitalized in the university neurology clinic in 2015 were retrospectively evaluated. Patients that have diabe...

Diabetes that is an important risk factor for ischemic stroke should also be well-treated in acute ischemic stroke patients for the secondary prevention against the next strokes. In the present study, we investigated the rate of the treatment changes in diabetic acute ischemic stroke patients during their stay at hospital.One hundred twelve acute diabetic ischemic stroke patients that were hospitalized in the university neurology clinic were retrospectiv...

Introduction: Vitamin D deficiency may be an important predisposing factor for infections as well as autoimmune diseases in old individuals. Neutrophil/lymphocyte ratio (NLR), is a meaningful indicator of inflammation throughout the body. In this study we aimed to show, whether or not a relationship exists between vitamin D levels and NLR in patients older than 65 years.Materials and method: Data of 82 patients over 65 years of age was retrospectively ex...

Introduction: Diabetes is characterized by an increase in abdominal fat. This results in a decrease in lean body mass and increase in insulin resistance. In this study, we aimed to evaluate the possible relationship between body composition and insulin regimen modality in type 1 diabetic patients.Materials and methods: Ninety-two type 1 diabetic patient followed in our institution were included in the study. Patients were classified into two groups accor...